BiologicalActivity
Glucocorticoidreceptor(GR)agonist.Displaysanti-inflammatoryandantioxidantproperties.Attenuatesapoptosisinoligodendrocytesafterinjurystimuli.UpregulatesexpressionofBcl-xLviadirectbindingoftheGR/STAT5complex.Neuroprotective.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
MethylprednisoloneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 374.47 |
| Formula | C22H30O5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 83-43-2 |
| PubChemID | 6741 |
| InChIKey | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight374.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.67mL | 13.35mL | 26.7mL |
| 5mM | 0.53mL | 2.67mL | 5.34mL |
| 10mM | 0.27mL | 1.34mL | 2.67mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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ProductDatasheets
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