Biological Activity
Potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.
Technical Data
| M. Wt | 218.29 |
| Formula | C13H18N2O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1465-16-3 |
| PubChem ID | 44404883 |
| InChI Key | MZZRFEIDRWKTKJ-UHFFFAOYSA-N |
| Smiles | OC1=C2C(N(C)C=C2CCN(C)C)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.83 | 100 | |
| ethanol | 2.18 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 218.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.58 mL | 22.91 mL | 45.81 mL |
| 5 mM | 0.92 mL | 4.58 mL | 9.16 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Sard et al (2005) SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist. Bioorg.Med.Chem.Letts. 15 4559 PMID:
Keywords: 1-Methylpsilocin, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, 5-HT2C, Receptors, 5-HT2C, Receptors, Tocris Bioscience
