Biological Activity
Use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
Compound Libraries
Mexiletine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 215.72 |
| Formula | C11H17NO.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 5370-01-4 |
| PubChem ID | 21467 |
| InChI Key | NFEIBWMZVIVJLQ-UHFFFAOYSA-N |
| Smiles | Cl.CC(N)COC1=C(C)C=CC=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.57 | 100 | |
| ethanol | 21.57 | 100 | |
| water | 21.57 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 215.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.64 mL | 23.18 mL | 46.36 mL |
| 5 mM | 0.93 mL | 4.64 mL | 9.27 mL |
| 10 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.93 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Franchini et al (2003) Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238 PMID: 14613326
Ates et al (2006) Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125 PMID: 16541198
Bellis et al (2006) Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300 PMID: 16921388
Keywords: Mexiletine hydrochloride, supplier, Na+, channel, blockers, antiarrhythmic, agent, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Ko1173, Ko, 1173, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
