Biological Activity
Non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.
Technical Data
| M. Wt | 300.83 |
| Formula | C18H20N2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 21535-47-7 |
| PubChem ID | 68551 |
| InChI Key | YNPFMWCWRVTGKJ-UHFFFAOYSA-N |
| Smiles | Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.01 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 300.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.62 mL | 33.24 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.65 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301 PMID: 6282060
Merck Index 12 6260 PMID:
Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527
Keywords: Mianserin hydrochloride, supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Non-selective, 5-HT2, 5-HT6, Receptors, Non-selective, 5-HT2, Tocris Bioscience
