Biological Activity
Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.
Technical Data
| M. Wt | 190.67 |
| Formula | C8H14N2O.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 139886-04-7 |
| PubChem ID | 9571001 |
| InChI Key | WEBMRZODPLSRKR-MLBSPLJJSA-N |
| Smiles | CN1CC(/C=N/OC)=CCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.07 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 190.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.24 mL | 26.22 mL | 52.45 mL |
| 5 mM | 1.05 mL | 5.24 mL | 10.49 mL |
| 10 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 50 mM | 0.1 mL | 0.52 mL | 1.05 mL |
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References
References are publications that support the products' biological activity.
Sedman et al (1995) Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 56 877 PMID: 10188788
Wood et al (1999) Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br.J.Pharmacol. 126 1620 PMID: 10323594
Schwarz et al (1999) Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 291 812 PMID: 10525104
Keywords: Milameline hydrochloride, supplier, Muscarinic, receptors, agonists, Acetylcholine, ACh, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience
