Biological Activity
Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.
Technical Data
| M. Wt | 282.81 |
| Formula | C15H22N2O.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 101152-94-7 |
| PubChem ID | 73416954 |
| InChI Key | GIGAIOSMEXBLQA-IBWNGBJLSA-N |
| Smiles | NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.28 | 100 | |
| water | 28.28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.68 mL | 35.36 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.07 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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References
References are publications that support the products' biological activity.
Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211 PMID: 3005901
Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems. J.Neural.Transm. 107 1345 PMID: 11145008
Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation. Anesth.Analg. 106 1309 PMID: 18349211
Keywords: Milnacipran hydrochloride, supplier, 5-HT, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, 5-HT, Transporters, Adrenergic, Transporters, 5-HT, Transporters, Tocris Bioscience
