Biological Activity
5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
Compound Libraries
Mosapride citrate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 614.02 |
| Formula | C21H25ClFN3O3.C6H8O7 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 112885-42-4 |
| PubChem ID | 119583 |
| InChI Key | HUZTYZBFZKRPFG-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)(CC(O)=O)CC(O)=O.ClC1=C(N)C=C(OCC)C(C(NCC2OCCN(CC3=CC=C(F)C=C3)C2)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.4 | 100 | |
| ethanol | 6.14 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 614.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.14 mL | 16.29 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yoshida et al (1989) AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties. Arch.Int.Pharmacodyn.Ther. 300 51 PMID: 2533479
Mine et al (1997) Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J.Pharmacol.Exp.Ther. 283 1000 PMID: 9399969
Yoshida et al (1993) Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneim.-Forsch. 43 1078 PMID:
Keywords: Mosapride citrate, supplier, 5-HT3, antagonists, 5-HT4, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT4, Receptors, 5-HT3, Receptors, 5-HT4, Receptors, Tocris Bioscience
