Biological Activity
Endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.
Technical Data
| M. Wt | 2699.07 |
| Formula | C120H188N34O35S |
| Sequence | FVPIFTYGELQRMQEKERNKGQ |
| Storage | Desiccate at -20°C |
| CAS Number | 52906-92-0 |
| PubChem ID | 16136567 |
| InChI Key | LVRVABPNVHYXRT-BQWXUCBYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2699.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.37 mL | 1.85 mL | 3.7 mL |
| 5 mM | 0.07 mL | 0.37 mL | 0.74 mL |
| 10 mM | 0.04 mL | 0.19 mL | 0.37 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.07 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Itoh (1997) Motilin and clinical application. Peptides 18 593 PMID: 9210180
Coulie et al (2001) Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J.Biol.Chem. 276 35518 PMID: 11461914
Huang et al (2005) Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am.J.Physiol.Gastrointest.Liver Physiol. 288 G23 PMID: 15591586
Keywords: Motilin (human, porcine), supplier, Endogenous, peptide, regulator, gastrointestinal, motility, Motilin, Receptors, Motilin, Receptors, Motilin, Receptors, Tocris Bioscience
