Biological Activity
Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
Compound Libraries
Mps BAY 2a is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 476.57 |
| Formula | C29H28N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1382477-96-4 |
| PubChem ID | 57381882 |
| InChI Key | MDYKTGNHXNTATG-UHFFFAOYSA-N |
| Smiles | CC(C)CNC1=NC(C2=CC=CC3=C2C=CC=N3)=CN4C1=NC=C4C5=CC=C(C(NC6CC6)=O)C=C5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.66 | 100 | |
| ethanol | 47.66 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 476.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.1 mL | 10.49 mL | 20.98 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.1 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532 PMID: 23933817
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