Biological Activity
Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.
Technical Data
| M. Wt | 114.1 |
| Formula | C4H6N2O2 |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 2763-96-4 |
| PubChem ID | 4266 |
| InChI Key | ZJQHPWUVQPJPQT-UHFFFAOYSA-N |
| Smiles | NCC1=CC(O)=NO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.41 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 114.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.76 mL | 43.82 mL | 87.64 mL |
| 5 mM | 1.75 mL | 8.76 mL | 17.53 mL |
| 10 mM | 0.88 mL | 4.38 mL | 8.76 mL |
| 50 mM | 0.18 mL | 0.88 mL | 1.75 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Akhondzadeh and Stone (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br.J.Pharmacol. 115 527 PMID: 7582468
Gleason et al (2009) The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 106 1257 PMID: 19213928
Jafari-Sabet and Jannat-Dastjerdi (2009) Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 202 5 PMID: 19447274
Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488 PMID: 5752907
Johnstone (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Keywords: Muscimol, supplier, Potent, GABAA, agonists, Partial, GABAC, Receptors, GABAA, Receptors, GABAA-rho, Receptors, GABAA, Receptors, Tocris Bioscience
