BiologicalActivity
Immunosuppressantprodrugofmycophenolicacid(MPA)(Cat.No.1505).HydrolyzedbyesterasestoreleaseMPA(areversIBLeinhibitorofinosinemonophosphatedehydrogenase).Usedtopreventorganrejectionaftertransplantation.Displaysinhibitoryactivityoflymphocytefunctions.Inhibitstype1collagenexpression,enhancesMMP-1expression,andreducesα-smoothmuscleactingeneexpression.
CompoundLibraries
MycophenolatemofetilisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 433.49 |
| Formula | C23H31NO7 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 128794-94-5 |
| PubChemID | 5281078 |
| InChIKey | RTGDFNSFWBGLEC-SYZQJQIISA-N |
| Smiles | O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.35 | 100 | |
| ethanol | 4.33 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight433.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.53mL | 23.07mL |
| 5mM | 0.46mL | 2.31mL | 4.61mL |
| 10mM | 0.23mL | 1.15mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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ProductDatasheets
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