Biological Activity
Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.
Technical Data
| M. Wt | 832.32 |
| Formula | C21H23N6Na4O18P3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 5502-96-5 |
| PubChem ID | 90488897 |
| InChI Key | NWKIGVGTZIAOCW-MCNGMCCKSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.62 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 832.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.2 mL | 6.01 mL | 12.01 mL |
| 5 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 10 mM | 0.12 mL | 0.6 mL | 1.2 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596 PMID: 19387438
Dammerman et al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678 PMID:
Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34 922 PMID:
Keywords: NAADP tetrasodium salt, supplier, general, Calcium, Signaling, Signalling, Agents, Ca2+, mobilization, beta-NAADP, β-NAADP, ryanodine, receptors, beta-NAADP, General, Calcium, Signaling, Agents, Ryanodine, Receptors, Ryanodine, Receptors, Tocris Bioscience
