Biological Activity
NO synthase inhibitor.
Compound Libraries
L-NAME hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 269.69 |
| Formula | C7H15N5O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 51298-62-5 |
| PubChem ID | 135193 |
| InChI Key | QBNXAGZYLSRPJK-JEDNCBNOSA-N |
| Smiles | N=C(NCCC[C@H](N)C(OC)=O)N[N+]([O-])=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.97 | 100 | |
| water | 26.97 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 269.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.08 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.42 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
Pfeiffer et al (1996) Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br.J.Pharmacol. 118 1433 PMID: 8832069
Keywords: L-NAME hydrochloride, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthase, NO, Synthases, iNOS, eNOS, nNOS, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience
