Biological Activity
High affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.
Technical Data
| M. Wt | 348.82 |
| Formula | C18H20N2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1539266-32-4 |
| PubChem ID | 90489019 |
| InChI Key | JQVAEIIIMVMJBO-UHFFFAOYSA-N |
| Smiles | OC(C=CC=C2)=C2CNCCC1=C(OC)C=C(C#N)C(OC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.88 | 100 | |
| water | 3.49 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 348.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.33 mL | 28.67 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hansen et al (2014) Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS.Chem.Neurosci. 5 243 PMID: 24397362
Fantegrossi et al (2014) Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. Psychopharmacology (Berl.) 232 1039 PMID: 25224567
Keywords: NBOH-2C-CN hydrochloride, supplier, serotonin, potent, selective, high, affinity, 5-ht, 5-ht2a, agonists, receptors, hallucinogen-like, 25CN-NBOH, 5-HT2A, Receptors, 5-HT2A, Receptors, Tocris Bioscience
