Biological Activity
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. NBQX disodium salt (Cat. No. 1044) also available.
Licensing Information
Sold with the permission of Novo Nordisk A/S
Compound Libraries
NBQX is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 336.28 |
| Formula | C12H8N4O6S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 118876-58-7 |
| PubChem ID | 3272524 |
| InChI Key | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C12)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 336.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814
Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874
Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146 PMID: 7504337
Zeman and Lodge (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781
Keywords: NBQX, supplier, Potent, selective, competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, neuroprotective, anticonvulsant, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
