Biological Activity
γ-Hydroxybutyric acid antagonist, anticonvulsant.
Technical Data
| M. Wt | 218.25 |
| Formula | C13H14O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 520505-01-5 |
| PubChem ID | 5875451 |
| InChI Key | UADPGHINQMWEAG-CSKARUKUSA-N |
| Smiles | OC1C2=C(CCCC1=C/C(O)=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.58 mL | 22.91 mL | 45.82 mL |
| 5 mM | 0.92 mL | 4.58 mL | 9.16 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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Product Datasheets
on-line. Please contact Customer Service
References
References are publications that support the products' biological activity.
King et al (1997) Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 104 1177 PMID: 9503264
Maitre et al (1990) A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 255 657 PMID: 2173754
Schmidt et al (1991) Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 203 393 PMID: 1773824
Keywords: NCS-382, supplier, antagonists, γ-hydroxybutyric, gamma-hydroxybutyric, acid, GABAA, GABAC, Receptors, GABAB, anticonvulsant, Miscellaneous, GABA, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience
