Biological Activity
Purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
Technical Data
| M. Wt | 1437.08 |
| Formula | C49H28F2N6Na6O23S6 |
| Storage | Desiccate at RT |
| CAS Number | 104869-26-3 |
| PubChem ID | 71433548 |
| InChI Key | QJFCMJZVZFAWGF-UHFFFAOYSA-H |
| Smiles | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]OOSC1=C2C(NC(=O)C3=CC(NC(=O)C4=CC(NC(=O)NC5=CC(=CC=C5)C(=O)NC5=CC(=CC=C5F)C(=O)NC5=CC=C(C6=CC(=CC(=C56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C4)=C(F)C=C3)=CC=C(C2=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 71.85 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 1437.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.7 mL | 3.48 mL | 6.96 mL |
| 5 mM | 0.14 mL | 0.7 mL | 1.39 mL |
| 10 mM | 0.07 mL | 0.35 mL | 0.7 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ullmann et al (2005) Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J.Med.Chem. 48 7040 PMID: 16250663
Moreschi et al (2006) Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J.Biol.Chem. 281 31419 PMID: 16926152
Keywords: NF 157, supplier, Selective, P2Y11/P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF157, P2X, Receptors, Purinergic, P2Y, Receptors, P2X, Receptors, Tocris Bioscience
