Biological Activity
A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
Technical Data
| M. Wt | 1401.1 |
| Formula | C49H30N6Na6O23S6 |
| Storage | Desiccate at -20°C |
| CAS Number | 202983-32-2 |
| PubChem ID | 4467 |
| InChI Key | RJMCMLNRWDKUDB-UHFFFAOYSA-H |
| Smiles | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.01 | 10 | |
| water | 35.03 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 1401.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.43 mL |
| 10 mM | 0.07 mL | 0.36 mL | 0.71 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5 PMID: 9683026
Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 387 245 PMID: 10650169
Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39 2044 PMID: 10963748
Keywords: NF 279, supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF279, P2X, Receptors, P2X, Receptors, Tocris Bioscience
