Biological Activity
P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.
Technical Data
| M. Wt | 1180.74 |
| Formula | C47H44N6Na4O17P4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1006028-37-0 |
| PubChem ID | 73755075 |
| InChI Key | GSMUPMANKNAMAS-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.81 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 1180.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.85 mL | 4.23 mL | 8.47 mL |
| 5 mM | 0.17 mL | 0.85 mL | 1.69 mL |
| 10 mM | 0.08 mL | 0.42 mL | 0.85 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812
Keywords: NF 546, supplier, NF546, p2y11, purinergic, receptors, agonists, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
