Biological Activity
Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
Technical Data
| M. Wt | 1683.94 |
| Formula | C75H118N20O22S |
| Sequence | MAGPHPVIVITGPHEE |
| Storage | Store at -20°C |
| CAS Number | 249537-73-3 |
| PubChem ID | 16135717 |
| InChI Key | QPMHUXBSHGAVGD-MCDIZDEASA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1683.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 5 mM | 0.12 mL | 0.59 mL | 1.19 mL |
| 10 mM | 0.06 mL | 0.3 mL | 0.59 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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References
References are publications that support the products' biological activity.
Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 2129 PMID: 10497131
Nagamoto-Combs and Combs (2010) Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 30 9641 PMID: 20631193
Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci. 101 7554 PMID:
Keywords: NFAT Inhibitor, supplier, NFAT, Inhibitor, VIVIT, peptide, inhibits, inhibitors, calcineurin, calcineurin-mediated, dephosphorylation, nuclear, factor, of, activated, T, cells, Protein, Ser/Thr, Phosphatases, VIVIT, peptide, NFAT, NFAT, Tocris Bioscience
