Biological Activity
High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
Compound Libraries
NIDA 41020 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 459.37 |
| Formula | C23H24Cl2N4O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 502486-89-7 |
| PubChem ID | 11037861 |
| InChI Key | KWDBQJRWPWTGPF-UHFFFAOYSA-N |
| Smiles | O=C(NN3CCCCC3)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(OC)C=C4)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.94 | 100 | |
| ethanol | 45.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 459.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.88 mL | 21.77 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Katoch-Rouse et al (2003) Synthesis, structure-activity relationship and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. J.Med.Chem. 46 642 PMID: 12570386
Miller et al (2007) Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity. Life Sci. 81 63 PMID: 17532007
Keywords: NIDA 41020, supplier, NIDA41020, cannabinoid, receptors, antagonists, CB1, selective, CB1, Receptors, CB1, Receptors, Tocris Bioscience
