![Tocris/[Lys5,MeLeu9,Nle10]-NKA(4-10)/3228/1/1 mg](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
Technical Data
| M. Wt | 804 |
| Formula | C39H65N9O9 |
| Sequence |
DKFVGLX (Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 137565-28-7 |
| PubChem ID | 10417908 |
| InChI Key | FIBMQAYBIOYAKI-HLYNNXGTSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.24 mL | 6.22 mL | 12.44 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 10 mM | 0.12 mL | 0.62 mL | 1.24 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.25 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91 PMID: 1658676
Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274
Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170 PMID: 17959748
Keywords: [Lys5,MeLeu9,Nle10]-NKA(4-10), supplier, Selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, NK2, Receptor, NK2, Receptor, Tocris Bioscience
