Biological Activity
Competitive, irreversible inhibitor of all three NOS isoforms.
Technical Data
| M. Wt | 248.28 |
| Formula | C7H16N4O2.CH3CO2H |
| Storage | Desiccate at RT |
| CAS Number | 53308-83-1 |
| PubChem ID | 135242 |
| InChI Key | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
| Smiles | CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 12.41 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 248.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.14 mL | 40.28 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828 PMID: 2049105
Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746 PMID: 1706208
Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170 PMID: 7540822
Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664 PMID: 3263652
Keywords: L-NMMA acetate, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience
