BiologicalActivity
GABAuptakeinhibitorthatdisplaysmoderateselectivityforBGT-1(mGAT-2)transporters(Kivaluesare1.4,15,19and41μMforhBGT-1,hGAT-3,hGAT-1andhGAT-2respectively).Anticonvulsive;inhibitssound-inducedtonicandclonicconvulsionsinDBA/2mice.Alsodisplaysaffinityatα1-andD2-receptors(IC50valuesare266and1632nMrespectively).
CompoundLibraries
NNC05-2090hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 451.01 |
| Formula | C27H30N2O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 184845-18-9 |
| PubChemID | 18782760 |
| InChIKey | WDFXPKKFSNMGOO-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=CC=C1)C1(O)CCN(CCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.1 | 100 | |
| ethanol | 5.64 | 12.5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight451.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.09mL | 22.17mL |
| 5mM | 0.44mL | 2.22mL | 4.43mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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ProductDatasheets
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