Biological Activity
Somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).
Technical Data
| M. Wt | 556.35 |
| Formula | C22H25N6Cl2SBr |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 199522-35-5 |
| PubChem ID | 9893924 |
| InChI Key | UREJDUPKGMFJRU-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C=C(CN(CCCNC(=S)NCCCC2=CNC=N2)C2=CC=C(Br)C=N2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.82 | 50 | |
| ethanol | 27.82 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 556.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 8.99 mL | 17.97 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Liu et al (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693 PMID: 9822540
Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255 PMID: 10101224
Keywords: NNC 26-9100, supplier, Selective, sst4, agonists, Receptors, Somatostatin, NNC269100, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
