Biological Activity
Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
Technical Data
| M. Wt | 319.31 |
| Formula | C19H13NO4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 175026-96-7 |
| PubChem ID | 5522952 |
| InChI Key | UFJGFNHRMPMALC-UHFFFAOYSA-N |
| Smiles | O=C2NC1=CC=CC4=C1C(C3=CC=CC=C3C4=O)=C2C(OCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.19 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 2004 PMID: 11384245
Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 2680 PMID: 21449566
Keywords: NQDI 1, supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, inhibits, MAP3K5, ASK1, ASK1, Tocris Bioscience
