BiologicalActivity
Selectiveactivatoroflarge-conductanceCa2+-activatedpotassiumchannels(BKCa,KCa1.1)(EC50=11μM).ActivatesBKchannelsinnativesmoothmusclecellsfromguineapigbladderandreducesspontaneousphasiccontractionsinbladderstripsexvivo.DisplaysnoeffectoncontractionsinducedbyahighK+concentrationorat65otherreceptorstested,includingL-andN-typeCa2+channels,Nav,KATPandhERGchannels.
CompoundLibraries
NS19504isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 269.16 |
| Formula | C10H9BrN2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 327062-46-4 |
| PubChemID | 727750 |
| InChIKey | HGWLTZOMQZIUBW-UHFFFAOYSA-N |
| Smiles | NC1=NC=C(CC2=CC=C(Br)C=C2)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.92 | 100 | |
| ethanol | 26.92 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight269.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.72mL | 18.58mL | 37.15mL |
| 5mM | 0.74mL | 3.72mL | 7.43mL |
| 10mM | 0.37mL | 1.86mL | 3.72mL |
| 50mM | 0.07mL | 0.37mL | 0.74mL |
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ProductDatasheets
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