Biological Activity
Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.
Technical Data
| M. Wt | 323.33 |
| Formula | C16H12F3NOS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 353262-04-1 |
| PubChem ID | 11837221 |
| InChI Key | ZUIJXKLTUFCDGO-UHFFFAOYSA-N |
| Smiles | O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.33 | 100 | |
| ethanol | 32.33 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 323.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.09 mL | 15.46 mL | 30.93 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.09 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432 PMID: 22891655
Keywords: NS 6180, supplier, NS6180, KCa3.1, potassium, channels, blockers, inhibitors, inhibits, potent, inflammatory, bowel, disease, gardos, channel, KCNN4, anti-inflammatory, Ca2+-Activated, Potassium, Channels, Ca2+-Activated, Potassium, Channels, Tocris Bioscience
