Biological Activity
Selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
Technical Data
| M. Wt | 438.65 |
| Formula | C28H42N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 82058-16-0 |
| PubChem ID | 5473838 |
| InChI Key | QFNJFVBKASKGEU-OCEACIFDSA-N |
| Smiles | CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)C1=CC(CN(CC)CC)=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.19 | 5mM with gentle warming | |
| ethanol | 4.39 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.4 mL | 22.8 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617
Keywords: NSC 33994, supplier, NSC33994, jak2, janus, tyrosine, kinase, inhibitors, inhibits, JAK, Kinase, JAK, Kinase, Tocris Bioscience
