Biological Activity
Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo.
Compound Libraries
NSC 3852 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 174.16 |
| Formula | C9H6N2O2 |
| Storage | Store at RT |
| CAS Number | 3565-26-2 |
| PubChem ID | 19103 |
| InChI Key | RZWRYPGAUIOOMK-UHFFFAOYSA-N |
| Smiles | OC1=C2N=CC=CC2=C(C=C1)N=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.42 | 100 | |
| ethanol | 1.74 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 174.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.74 mL | 28.71 mL | 57.42 mL |
| 5 mM | 1.15 mL | 5.74 mL | 11.48 mL |
| 10 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.15 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Martirosyan et al (2004) Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochem.Pharmacol. 68 1729 PMID: 15450938
Martirosyan et al (2006) Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J.Pharmacol.Exp.Ther. 317 546 PMID: 16497787
Keywords: NSC 3852, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, NSC3852, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
