Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Technical Data
| M. Wt | 271.33 |
| Formula | C15H13NO2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 141992-47-4 |
| PubChem ID | 3004085 |
| InChI Key | KFAKESMKRPNZTM-UHFFFAOYSA-N |
| Smiles | COC1=C2NC3=CC=CC=C3C(=S)C2=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.13 | 100 | |
| ethanol | 2.71 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 271.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.43 mL | 36.86 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.37 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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References
References are publications that support the products' biological activity.
Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279 PMID: 10632371
McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525 PMID: 15123247
Keywords: NSC 625987, supplier, Cyclin-dependent, protein, kinases, 4, cdk4, inhibitors, inhibits, Cdk, NSC625987, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
