BiologicalActivity
SelectiveinhibitoroftheE2ubiquitin(Ub)conjugatingenzymeUBE2N(Ubc13).InhibitsUBE2N-UbconjugationandactivityoftheUBE2N-Ueva1Acomplex.HasnoeffectonUbcH5cactivity.InhibitsNF-κBactivationindiffuselargeB-celllymphoma(DLBCL)cells.InhibitscellgrowthandinducesapoptosisinDLBCLandneuroblastoma(NB)celllines.SupressesNBcellxenografttumorgrowthinvivo.
CompoundLibraries
NSC697923isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 267.26 |
| Formula | C11H9NO5S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 343351-67-7 |
| PubChemID | 394449 |
| InChIKey | GAUHIPWCDXOLCZ-UHFFFAOYSA-N |
| Smiles | CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.73 | 100 | |
| ethanol | 6.68 | 25mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight267.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.74mL | 18.71mL | 37.42mL |
| 5mM | 0.75mL | 3.74mL | 7.48mL |
| 10mM | 0.37mL | 1.87mL | 3.74mL |
| 50mM | 0.07mL | 0.37mL | 0.75mL |
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ProductDatasheets
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