BiologicalActivity
SelectivelyinhibitsSTAT3DNA-bindingactivityinvitro(IC50valuesare86,160,and>300μMforSTAT3-STAT3,STAT1-STAT3andSTAT1-STAT1DNA-bindingactivityrespectively).BlocksgrowthandinducesapoptosispreferentiallyintumorcellsthatcontainpersistentlyactiveSTAT3invitroandarreststumorgrowthinamurinexenograftmodelinvivo.
CompoundLibraries
NSC74859isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 365.36 |
| Formula | C16H15NO7S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 501919-59-1 |
| PubChemID | 252682 |
| InChIKey | HWNUSGNZBAISFM-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.54 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight365.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.74mL | 13.69mL | 27.37mL |
| 5mM | 0.55mL | 2.74mL | 5.47mL |
| 10mM | 0.27mL | 1.37mL | 2.74mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |
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ProductDatasheets
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