Biological Activity
Selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
Technical Data
| M. Wt | 508.07 |
| Formula | C25H33N3O4S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 191931-56-3 |
| PubChem ID | 124081021 |
| InChI Key | BKCQHNDMUNWNQC-GMIOCVINSA-N |
| Smiles | O=S(NC[C@@H](CC3)CC[C@H]3CNCC2CCC1=CC=CC=C1C2)(C4=C([N+]([O-])=O)C=CC=C4)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.81 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 508.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.84 mL | 19.68 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767 PMID: 12067557
Keywords: NTNCB hydrochloride, supplier, Potent, selective, non-peptidic, Y5, antagonists, Neuropeptide, Y, Receptors, NPY, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience
