Biological Activity
Potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC50 = 38 nM). Exhibits >150-fold selectivity for NTS2 over NTS1.
Compound Libraries
NTRC 824 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 553.55 |
| Formula | C25H26F3N3O6S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1623002-61-8 |
| PubChem ID | 101873359 |
| InChI Key | SOOLLEBJNGCDOZ-FQEVSTJZSA-N |
| Smiles | O=C(C(F)(F)F)C2=CN(CC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=C(NS(C3=CC=C(C)C=C3)(=O)=O)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.35 | 100 | |
| ethanol | 55.35 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 553.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.03 mL | 18.07 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Thomas et al (2014) Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 57 7472 PMID: 25157640
Keywords: NTRC 824, supplier, NTRC824, neurotensin, receptors, NTS2, non-peptide, potent, selective, antagonists, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience
