Biological Activity
Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
Technical Data
| M. Wt | 232.37 |
| Formula | C6H4N2S4 |
| Storage | Store at -20°C |
| CAS Number | 1450644-28-6 |
| PubChem ID | 72201043 |
| InChI Key | MLRAMCAHIWHWRM-UHFFFAOYSA-N |
| Smiles | C1(SSC2=CC=NS2)=CC=NS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 232.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.3 mL | 21.52 mL | 43.03 mL |
| 5 mM | 0.86 mL | 4.3 mL | 8.61 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.3 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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References
References are publications that support the products' biological activity.
Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207
Keywords: NU 9056, supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience
