Biological Activity
Potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
Compound Libraries
NVP 231 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 431.55 |
| Formula | C25H25N3O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 362003-83-6 |
| PubChem ID | 4096211 |
| InChI Key | MVSSJPGNLQPWSW-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=CC=C3)NC2=NC(C=C1)=C(S2)C=C1NC(C45CC(C6)CC(CC6C5)C4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.16 | 100 | |
| ethanol | 2.16 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 431.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Graf et al (2009) A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 384 166 PMID: 18831956
Niwa et al (2009) Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77 389 PMID: 19323974
Graf et al (2009) Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 74 925 PMID:
Keywords: NVP 231, supplier, NVP231, potent, reversible, selective, ceramide, kinase, CerK, inhibitors, inhibits, Other, Kinases, Other, Kinases, Tocris Bioscience
