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Tocris Bioscience(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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4000-520-616
当前位置: 首页 > 产品中心 > kinase > Tocris/NVP ADW 742/5247/50/50毫克
商品详细Tocris/NVP ADW 742/5247/50/50毫克
Tocris/NVP ADW 742/5247/50/50毫克
Tocris/NVP ADW 742/5247/50/50毫克
商品编号: 5247/50
品牌: Tocris Bioscience
市场价: ¥20900.00
美元价: 12540.00
产地: 美国(厂家直采)
公司:
产品分类: 激酶
公司分类: kinase
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:ATP-competitiveinhibitorofIGF1R
ChemicalName:5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ATP-competitiveinhibitorofIGF1R(IC50intherangeof0.1-0.2μM).Alsoinhibitsc-Kitkinaseactivity(IC50intherangeof3-5μM).ExhibitsasynergisticeffectwithImatinib,enhancingthesensitivityofmultiplesmallcelllungcancercelllinestothechemotherapeuticsetoposide(Cat.No.1226)andcarboplatin(Cat.No.2626).

CompoundLibraries

NVPADW742isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt453.58
FormulaC28H31N5O
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber475488-23-4
PubChemID9825149
InChIKeyLSFLAQVDISHMNB-UHFFFAOYSA-N
SmilesNC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO22.6850
ethanol4.5410

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight453.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.2mL11.02mL22.05mL
5mM0.44mL2.2mL4.41mL
10mM0.22mL1.1mL2.2mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet