BiologicalActivity
ATP-competitiveinhibitorofIGF1R(IC50intherangeof0.1-0.2μM).Alsoinhibitsc-Kitkinaseactivity(IC50intherangeof3-5μM).ExhibitsasynergisticeffectwithImatinib,enhancingthesensitivityofmultiplesmallcelllungcancercelllinestothechemotherapeuticsetoposide(Cat.No.1226)andcarboplatin(Cat.No.2626).
CompoundLibraries
NVPADW742isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 453.58 |
Formula | C28H31N5O |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 475488-23-4 |
PubChemID | 9825149 |
InChIKey | LSFLAQVDISHMNB-UHFFFAOYSA-N |
Smiles | NC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 22.68 | 50 | |
ethanol | 4.54 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight453.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.2mL | 11.02mL | 22.05mL |
5mM | 0.44mL | 2.2mL | 4.41mL |
10mM | 0.22mL | 1.1mL | 2.2mL |
50mM | 0.04mL | 0.22mL | 0.44mL |