4000-520-616
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Tocris Bioscience(优势品牌)
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4000-520-616
当前位置: 首页 > 产品中心 > protease > Tocris/NVP DPP 728 dihydrochloride/3506/50/50 mg
商品详细Tocris/NVP DPP 728 dihydrochloride/3506/50/50 mg
Tocris/NVP DPP 728 dihydrochloride/3506/50/50 mg
Tocris/NVP DPP 728 dihydrochloride/3506/50/50 mg
商品编号: 3506/50
品牌: Tocris Bioscience
市场价: ¥16500.00
美元价: 9900.00
产地: 美国(厂家直采)
公司:
产品分类: 蛋白酶类
公司分类: protease
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:Potent,orallyactivedipeptidylpeptidaseIV(DPP-IV)inhibitor
ChemicalName:6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,orallyactivedipeptidylpeptidase(DPP)-IVinhibitor(Ki=11nM,IC50=14nM)thatdisplays>15000-foldselectivityoverDPP-IIandarangeofproline-cleavingproteases.Exhibitsantidiabeticactivityinvivo;improvesglucosetolerance,increasesglucagon-likepeptide1(GLP-1)andinsulinlevels,augmentsinsulinsecretionandGLUT2levels,andreduces(preserves)isletsize.

CompoundLibraries

NVPDPP728dihydrochlorideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt371.27
FormulaC15H18N6O.2HCl
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber207556-62-5
PubChemID9799555
InChIKeyVNACOBVZDCLAEV-GXKRWWSZSA-N
SmilesO=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.13100
water37.13100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight371.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.69mL13.47mL26.93mL
5mM0.54mL2.69mL5.39mL
10mM0.27mL1.35mL2.69mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet