Biological Activity
Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration.
Licensing Information
Sold with the permission of INSERM and BIOPROJET
Technical Data
| M. Wt | 365.47 |
| Formula | C22H27N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 149649-22-9 |
| PubChem ID | 3408722 |
| InChI Key | IDZASIQMRGPBCQ-UHFFFAOYSA-N |
| Smiles | CCCCN1CCCC1CNC(=O)C1=C(OC)C2=CC=CC=C2C(=C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 36.55 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 365.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.68 mL | 27.36 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337
Richtand et al (2000) The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 867 239 PMID: 10837819
Sautel et al (1995) Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J.Pharmacol.Exp.Ther. 275 1239 PMID: 8531087
Keywords: Nafadotride, supplier, potent, preferential, D3, antagonists, Dopamine, Receptors, dopaminergic, D3, Receptors, D3, Receptors, Tocris Bioscience
