Biological Activity
Opioid receptor antagonist; displays a longer half life than Naloxone (Cat. No. 0599). Exhibits neuroprotective effects after traumatic brain injury in the rat. Deuterated version, Nalmefene d3 (Cat. No. 3971), also available.
Compound Libraries
Nalmefene hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 375.89 |
| Formula | C21H25NO3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58895-64-0 |
| PubChem ID | 5388881 |
| InChI Key | GYWMRGWFQPSQLK-OPHZJPRHSA-N |
| Smiles | C=C3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(CC6CC6)CC4)[C@@](O)2CC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.59 | 100 | |
| water | 37.59 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 375.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.3 mL | 26.6 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Vink et al (1990) Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats. J.Neurosci. 10 3524 PMID: 2230942
Keywords: Nalmefene hydrochloride, supplier, opioid, receptor, antagonist, antagonists, Miscellaneous/Non-selective, Opioids, Miscellaneous/Non-selective, Opioids, Tocris Bioscience
