Biological Activity
Potent opioid antagonist, selective for μ1 receptors.
Technical Data
| M. Wt | 723.69 |
| Formula | C38H42N4O6.2HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 880759-65-9 |
| PubChem ID | 90479735 |
| InChI Key | VIAIHLLKDJKEKM-JNHLASQBSA-N |
| Smiles | OC(C(N(CC=C)CC%10)C6)7C2%10C1=C6C=CC(O)=C1OC2/C(CC7)=N/N=C3CCC8(O)C49C/3OC5=C(O)C=CC(CC8N(CC=C)CC9)=C45.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 25 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 723.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.38 mL | 6.91 mL | 13.82 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 10 mM | 0.14 mL | 0.69 mL | 1.38 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168
Keywords: Naloxonazine dihydrochloride, supplier, Selective, antagonists, μ-opioid, mu-opioid, μ1-opioid, mu1-opioid, MOP, Receptors, OP3, Mu, Opioid, Receptors, Mu, Opioid, Receptors, Tocris Bioscience
