Biological Activity
Opioid antagonist.
Technical Data
| M. Wt | 363.84 |
| Formula | C19H21NO4.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 357-08-4 |
| PubChem ID | 5464092 |
| InChI Key | RGPDIGOSVORSAK-STHHAXOLSA-N |
| Smiles | O=C3[C@H]4[C@]25C1=C(O4)C(O)=CC=C1C[C@@H](N(CC5)CC=C)[C@@](O)2CC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 36.38 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 363.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Pinelli and Trivulzio (1997) Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J.Pharmacol.Toxicol.Methods 38 117 PMID: 9523765
Spivak et al (1997) Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 52 983 PMID: 9415708
Olson et al (1996) Endogenous opiates: 1995. Peptides 17 1421 PMID:
Merck Index 12 6449 PMID:
Keywords: Naloxone hydrochloride, supplier, Broad, spectrum, opioid, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, Miscellaneous/Non-selective, Opioids, Tocris Bioscience
