Biological Activity
Selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.
Licensing Information
Sold with the permission of the University of Minnesota
Compound Libraries
Naltriben mesylate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 511.59 |
| Formula | C26H25NO4.CH3SO3H |
| Storage | Desiccate at RT |
| CAS Number | 122517-78-6 |
| PubChem ID | 45073482 |
| InChI Key | XRRFZOCDAWPIBB-XXCZMEBESA-N |
| Smiles | CS(=O)(O)=O.O[C@@]24[C@]3([C@@H]7C(O6)=C(C5=C6C=CC=C5)C4)C1=C(O7)C(O)=CC=C1CC2N(CC8CC8)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.58 | 50mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.77 mL | 19.55 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of morphine dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738
Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846
Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992
Keywords: Naltriben mesylate, supplier, δ2-opioid, delta2-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
