Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Compound Libraries
1-Naphthyl PP1 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 317.39 |
| Formula | C19H19N5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 221243-82-9 |
| PubChem ID | 4877 |
| InChI Key | XSHQBIXMLULFEV-UHFFFAOYSA-N |
| Smiles | NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.35 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 317.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.75 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395 PMID: 11014197
Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627 PMID:
Keywords: 1-Naphthyl PP1, supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1, 1-NA-PP, 1, Src, Kinases, Abl, Kinase, Src, Kinases, Tocris Bioscience
