Tocris/Necrostatin-1/2324/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Necrostatin-1/2324/50/50 mg

Tocris/Necrostatin-1/2324/50/50 mg

商品编号： 2324/50

品牌： Tocris Bioscience

市场价： ¥9180.00

美元价： 5508.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:RIPK1inhibitor;inhibitsnecroptosis

ChemicalName:5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ATP-competitive,allostericinhibitorofreceptor-interactingproteinkinase1(RIPK1)(EC₅₀=182nM).Blocksnon-apoptoticcelldeathviainhibitionofaspecificcellularpathway,necroptosis,whichleadstonecrosis(EC₅₀=494nM).Reducesischemicbraininjuryinamousemodelofstroke.

CompoundLibraries

Necrostatin-1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	259.33
Formula	C₁₃H₁₃N₃OS
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	4311-88-0
PubChemID	2828334
InChIKey	TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Smiles	CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	115.7	30
	ethanol	3.89	15mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight259.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.86mL	19.28mL	38.56mL
5mM	0.77mL	3.86mL	7.71mL
10mM	0.39mL	1.93mL	3.86mL
50mM	0.08mL	0.39mL	0.77mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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TechnicalData

SolubilityData

PreparingStockSolutions

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