Biological Activity
Precursor of biopterin synthesis. Synthesized in response to interferon-γ stimulation; used as a marker of T helper cell-induced immune activation. Also an indicator of oxidative stress; modulates the effects of reactive oxygen species (ROS).
Technical Data
| M. Wt | 253.21 |
| Formula | C9H11N5O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2009-64-5 |
| PubChem ID | 448839 |
| InChI Key | BMQYVXCPAOLZOK-XINAWCOVSA-N |
| Smiles | OC[C@@H](O)[C@@H](O)C2=NC1=C(N=C2)N=C(N)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.06 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 253.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.95 mL | 19.75 mL | 39.49 mL |
| 5 mM | 0.79 mL | 3.95 mL | 7.9 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Murr et al (2002) Neopterin as a marker for immune system activation. Curr.Drug Metab. 3 175 PMID: 12003349
Huber et al (1984) Immune response-associated production of neopterin. J.Exp.Med. 160 310 PMID: 6429267
Keywords: (D)-(+)-Neopterin, supplier, cytokines, IFN-gamma, IFN-g, IFN-γ, immune, markers, oxidative, stress, indicators, Cytokines, Cytokines, Tocris Bioscience
