Biological Activity
Endogenous tachykinin peptide; more potent bronchoconstrictor than Substance P.
Technical Data
| M. Wt | 1133.3 |
| Formula | C50H80N14O14S |
| Sequence |
HKTDSFVGLM (Modifications: Met-10 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 86933-74-6 |
| PubChem ID | 5311311 |
| InChI Key | HEAUFJZALFKPBA-JPQUDPSNSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1133.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.88 mL | 4.41 mL | 8.82 mL |
| 5 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 10 mM | 0.09 mL | 0.44 mL | 0.88 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lippe et al (1997) Neurokinin A-induced vasoconstriction and muscular contraction in the rat isolated stomach: mediation by distinct and unusual neurokinin A2 receptors. J.Pharmacol.Exp.Ther. 281 1294 PMID: 9190865
Nawa et al (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306 32 PMID: 6195531
Sherwood et al (1997) Bronchoconstrictor and respiratory effects of neurokinin A in dogs. J.Pharmacol.Exp.Ther. 283 788 PMID: 9353399
Keywords: Neurokinin A (porcine), supplier, Endogenous, tachykinin, peptide, Non-Selective, Neurokinin, Receptors, agonists, NeurokininA, NKA, Other, Tachykinin, Other, Tachykinin, Tocris Bioscience
