Biological Activity
Endogenous peptide regulating blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Also decreases food intake and body weight, increases body temperature and heat production, and inhibits gastric acid secretion via the CRH system following central administration in vivo.
Technical Data
| M. Wt | 2643 |
| Formula | C124H180N34O31 |
| Sequence |
YKVNEYQGPVAPSGGFFLFRPRN (Modifications: Asn-23 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 117505-80-3 |
| PubChem ID | 71311710 |
| InChI Key | YYDRKWCPVLDJJD-XOXVDEAXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2643. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 5 mM | 0.08 mL | 0.38 mL | 0.76 mL |
| 10 mM | 0.04 mL | 0.19 mL | 0.38 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Minamino et al (1985) Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 130 1078 PMID: 3841690
Mondal et al (2003) Neuromedin U acts in the cental nervous system to inhibit gastric acid secretion via CRH system. Am.J.Physiol.Gastrointest.Liver Physiol. 284 G963 PMID: 12584108
Szekeres et al (2000) Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J.Biol.Chem. 275 20247 PMID: 10811630
Keywords: Neuromedin U (rat), supplier, NMU, Receptors, agonists, NeuromedinU, (rat), Neuromedin, U, Receptors, Neuromedin, U, Receptors, Tocris Bioscience
