Biological Activity
Endogenous antiopioid peptide, implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes.
Technical Data
| M. Wt | 1978.19 |
| Formula | C90H132N26O25 |
| Sequence |
AGEGLNSQFWSLAAPQRF (Modifications: Phe-18 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 192387-38-5 |
| PubChem ID | 90488726 |
| InChI Key | DYSIROANKWMSGC-KWFINLGMSA-N |
| Smiles | [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1978.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 5 mM | 0.1 mL | 0.51 mL | 1.01 mL |
| 10 mM | 0.05 mL | 0.25 mL | 0.51 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242
Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260
Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558
Keywords: Neuropeptide AF (human), supplier, Implicated, pain, modulation, Anti-opioids, neuropeptides, FF, AF, NPFF, Receptors, NPAF, Neuropeptide, NPAF, (human, FMRFamide-related), Miscellaneous/Non-selective, Opioids, Neuropeptide, FF/AF, Receptors, Neuropeptide, FF/AF, Receptors, Tocris Bioscience
